Реакция #2186196

Уравнение реакции

1-(2-Fluoro-ethyl)-7-hydroxy-1,2,3,4-tetrahydro-quinoline-6-carbaldehyde

(6-chloro-imidazo[1,2-a]pyridin-2-yl)-acetic acid methyl ester

piperidine

→

desired product

Выход 67.4%

3-(6-Chloro-imidazo[1,2-a]pyridin-2-yl)-8-(2-fluoro-ethyl)-5,6,7,8-tetrahydro-1-oxa-8-aza-anthracen-2-one

Выход 67.4%

Растворители

benzene

acetonitrile

Условия реакции

Обработка

1. 1
   Температураrefluxed for 18 h
2. 2
   Другоеto reach room temperature
3. 3
   Фильтрацияthe precipitate filtered
4. 4
   Промывкаwashed with acetonitrile
5. 5
   Другоеdried under high vacuum

Методика

200 mg (0.896 mmol) 1-(2-Fluoro-ethyl)-7-hydroxy-1,2,3,4-tetrahydro-quinoline-6-carbaldehyde and 201 mg (1 eq.) (6-chloro-imidazo[1,2-a]pyridin-2-yl)-acetic acid methyl ester in 6 mL benzene and 3 mL acetonitrile are treated with 0.177 mL (2 eq.) piperidine and refluxed for 18 h. The reaction mixture is allowed to reach room temperature and the precipitate filtered, washed with acetonitrile and dried under high vacuum to yield 240 mg (67%) of desired product as a yellow powder.

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