Реакция #2186191

Уравнение реакции

4-[4-(2-Fluoro-ethyl)-piperazin-1-yl]-2-hydroxy-benzaldehyde

benzothiazol-2-yl-acetic acid methyl ester

piperidine

→

desired product

Выход 55.0%

3-Benzothiazol-2-yl-7-[4-(2-fluoro-ethyl)-piperazin-1-yl]-chromen-2-one

Выход 55.0%

Растворители

benzene

acetonitrile

Условия реакции

Обработка

1. 1
   Другоеto reach room temperature
2. 2
   Фильтрацияthe precipitate filtered off
3. 3
   Промывкаwashed with diethylether
4. 4
   Другоеdried under high vacuum

Методика

200 mg (0.793 mmol) 4-[4-(2-Fluoro-ethyl)-piperazin-1-yl]-2-hydroxy-benzaldehyde and 164 mg (1 eq.) benzothiazol-2-yl-acetic acid methyl ester are heated to reflux for 3 h in 5 mL benzene and 2.5 mL acetonitrile, in the presence of 0.157 mL (2 eq.) piperidine. The reaction mixture is allowed to reach room temperature and the precipitate filtered off, washed with diethylether and dried under high vacuum to yield 90 mg (55%) of desired product as a yellow powder (melting point: 246° C.).

Источник