Реакция #216148

Уравнение реакции

product

3-(1-Methyl-1,2,3,6-tetrahydro-4-pyridyl)-1H-indole-5-carbaldehyde

hydantoin

ammonium acetate

→

desired product

Выход 76.0%

5-[3-(1-Methyl-1,2,3,6-tetrahydro-4-pyridyl)-1H-indol-5-ylmethylene]-2,4-imidazolidinedione

Выход 76.0%

Растворители

acetic acid

Условия реакции

Обработка

1. 1
   ТемператураThe mixture was cooled
2. 2
   Фильтрацияthe resulting precipitate filtered off
3. 3
   Другоеdried

Методика

A mixture of the product from step (b) (2.4 g), hydantoin (Aldrich, 0.98 g) and ammonium acetate (0.74 g) in glac. acetic acid (2.4 ml) was heated at 120° C. for 4 hours. The mixture was cooled and the resulting precipitate filtered off and dried to give the desired product as a yellow solid (2.4 g).

Источник