Реакция #2161255

Уравнение реакции

4-(trifluoromethoxy)phenyl isocyanate

ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate

→

Ethyl 1-methyl-4-[({[4-(trifluoromethoxy)phenyl]amino}carbonyl)amino]-1H-imidazole-2-carboxylate

Растворители

THF

Условия реакции

Обработка

1. 1
   Другоеsynthesis in analogy to Example 4A step 3
2. 2
   ФильтрацияThe reaction mixture is filtered
3. 3
   Концентрированиеthe filtrate is concentrated in vacuo
4. 4
   Другоеpurified chromatographically

Методика

Under argon, 1.46 g (7.21 mmol) of 4-(trifluoromethoxy)phenyl isocyanate are added to 1.22 g (3.61 mmol) of ethyl 4-amino-1-methyl-1H-imidazole-2-carboxylate (synthesis in analogy to Example 4A step 3, or also according to Tetrahedron Lett. 2003, 44, 1607 and the literature cited therein) in 50 ml of THF, and the mixture is stirred at room temperature overnight. The reaction mixture is filtered and the filtrate is concentrated in vacuo and purified chromatographically.

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