Реакция #2161253

Уравнение реакции

cyclohexane ethyl acetate

potassium carbonate

iodomethane

ethyl 4-nitro-1H-imidazole-2-carboxylate

→

Ethyl 1-methyl-4-nitro-1H-imidazole-2-carboxylate

Растворители

acetone

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling
2. 2
   Фильтрацияthe mixture is filtered
3. 3
   Промывкаthe residue is washed with dichloromethane
4. 4
   ДругоеThe solid obtained
5. 5
   Другоеis dried in vacuo

Методика

6.80 g (36.7 mmol) of ethyl 4-nitro-1H-imidazole-2-carboxylate are dissolved in 140 ml of acetone, and 11.2 g (80.8 mmol) of potassium carbonate and 4.57 ml (73.5 mmol) of iodomethane are added. The mixture is then stirred at 60° C. for 4 h. According to TLC (cyclohexane/ethyl acetate 2:1), the starting material has been converted completely. After cooling, the mixture is filtered, the residue is washed with dichloromethane and the filtrate is freed from the solvent. The solid obtained is dried in vacuo.

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