Реакция #2161251

Уравнение реакции

ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate

hydrogen

→

Ethyl 4-amino-1-(cyclopropylmethyl)-1H-imidazole-2-carboxylate

Растворители

THF

Условия реакции

Обработка

1. 1
   ФильтрацияThe catalyst is filtered off
2. 2
   Концентрированиеthe filtrate is concentrated in vacuo
3. 3
   ДругоеThe concentration residue is directly used further for the next reaction

Методика

3.89 g (16.26 mmol) of ethyl 1-(cyclopropylmethyl)-4-nitro-1H-imidazole-2-carboxylate are dissolved in 50 ml of THF, and a spatula tip of Raney nickel is added. In a hydrogenation apparatus, the reaction mixture is hydrogenated with hydrogen at room temperature. The catalyst is filtered off and the filtrate is concentrated in vacuo. The concentration residue is directly used further for the next reaction.

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