Реакция #2161248

Уравнение реакции

ammonium formate

ethyl 1-benzyl-1H-imidazole-2-carboxylate

ammonium formate

→

Ethyl imidazole-2-carboxylate

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ТемператураThe reaction mixture is heated
2. 2
   Температураunder reflux for about 6 h
3. 3
   ТемператураAfter cooling
4. 4
   Фильтрацияthe catalyst is filtered off
5. 5
   Концентрированиеthe filtrate is concentrated in vacuo
6. 6
   ДругоеThe product that crystallizes out during this operation
7. 7
   Другоеis triturated with 80 ml of ice-water
8. 8
   Фильтрацияcollected by suction filtration

Методика

34.7 g (150.9 mmol) of ethyl 1-benzyl-1H-imidazole-2-carboxylate are dissolved in 1005 ml of ethanol, and 34 g of ammonium formate are added. The reaction mixture is heated under reflux for about 6 h. A total of 8 g of 10% palladium-on-carbon and 18 g of ammonium formate are thereby added in small portions. After cooling, the catalyst is filtered off and the filtrate is concentrated in vacuo. The product that crystallizes out during this operation is triturated with 80 ml of ice-water and collected by suction filtration.

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