Реакция #215940

Уравнение реакции

3,5-dimethyl-4-hydroxybenzonitrile

5-chloro-1-pentyne

→

title compound

Выход 99.4%

3,5-Dimethyl-4-(3-ethinylpropoxy)benzonitrile

Выход 99.4%

Условия реакции

Обработка

1. 1
   Другоеthere was obtained a red-brown oil which
2. 2
   Другоеwas purified by chromatography (Silica Gel 60, 15% ethyl acetate in hexanes)

Методика

Following the procedure of Example 1c and using 14.7 g (100 mmol) of 3,5-dimethyl-4-hydroxybenzonitrile and substituting 5-chloro-1-pentyne (12.7 mL, 120 mmol) for the product of Example 1b, there was obtained a red-brown oil which was purified by chromatography (Silica Gel 60, 15% ethyl acetate in hexanes) to give pure title compound (21.2 g, 99.4%) as a pale yellow oil.

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