Реакция #215919

Уравнение реакции

3,5-di-t-butyl-4-hydroxybenzaldehyde

hydantoin

acetic acid

→

product

Выход 50.6%

5-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]2,4-imidazolidinedione

Выход 50.6%

Растворители

water

Условия реакции

Обработка

1. 1
   Температураheated to reflux
2. 2
   Фильтрацияthe precipitate is filtered off
3. 3
   Промывкаrinsed with water three times
4. 4
   Другоеdried
5. 5
   ДругоеRecrystallization from acetonitrile

Методика

A mixture of 3,5-di-t-butyl-4-hydroxybenzaldehyde (7.0 g, 30 mmoles), hydantoin (3.0 g, 30 mmoles), μ-alanine (1.4 g, 16 mmoles), and acetic acid (40 ml) is stirred under an inert atmosphere and heated to reflux. After 48 hours the mixture is stirred into water (300 ml), and the precipitate is filtered off, rinsed with water three times, and dried. Recrystallization from acetonitrile gave the pure product (4.8 g), mp 251°-252° C.

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