Реакция #215917

Уравнение реакции

4-hydroxy-3-methoxybenzaldehyde

hydantoin

β-alanine

acetic acid

→

product

Выход 42.7%

5- [(4-Hydroxy-3-methoxyphenyl )methylene ]-2,4-imidazolidinedione

Выход 42.7%

Растворители

water

Условия реакции

Обработка

1. 1
   Температураheated to reflux
2. 2
   Фильтрацияthe precipitate is filtered off
3. 3
   Промывкаrinsed successively with water (3X), ethanol (2X), and ether (2X)
4. 4
   Другоеdried
5. 5
   ДругоеRecrystallization from methanol

Методика

A mixture of 4-hydroxy-3-methoxybenzaldehyde (4.6 g, 30 mmoles), hydantoin (3.0 g, 30 mmoles), β-alanine (1.4 g, 16 mmoles), and acetic acid (40 ml) is stirred under an inert atmosphere and heated to reflux. After 4 hours the mixture is stirred into water (350 ml) and the precipitate is filtered off, rinsed successively with water (3X), ethanol (2X), and ether (2X), and dried. Recrystallization from methanol afforded the pure product (3.0 g), mp 272°-273° C.

Источник