Реакция #214756

Уравнение реакции

N-(2-chloro-6-nitrobenzyl)-D-alanine ethyl ester

hydrogen

→

N-(2-amino-6-chlorobenzyl)-D-alanine ethyl ester

Выход 99.0%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ФильтрацияThe catalyst was then filtered off
2. 2
   Другоеthe filtrate was evaporated to dryness

Методика

A solution of 14.3 g of N-(2-chloro-6-nitrobenzyl)-D-alanine ethyl ester in 50 ml of ethanol was hydrogenated in the presence of 1 g of Raney nickel. 3.35 liters of hydrogen were taken up in 2 hours. The catalyst was then filtered off and the filtrate was evaporated to dryness. There were obtained 12.6 g (99% of theory) of N-(2-amino-6-chlorobenzyl)-D-alanine ethyl ester; nD23 =1.5405; [α]D =+55.8° (c=1% in ethanol).

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