Реакция #2146785

Уравнение реакции

[2-(1-benzyl-1H-pyrazol-4-yl)-7-benzyloxy-6-methoxy-benzofuran-3-yl]-(3,4,5-trimethoxyphenyl)-methanone

→

[7-Hydroxy-6-methoxy-2-(1H-pyrazol-4-yl)-benzofuran-3-yl]-(3,4,5-trimethoxyphenyl)-methanone

Растворители

ethyl acetate

methanol

Условия реакции

Обработка

1. 1
   ФильтрацияAfter this time the reaction mixture was filtered through celite
2. 2
   Другоеthe solvent removed under vacuum
3. 3
   ДругоеThe crude residue was purified by preparative thin layer chromatography
4. 4
   Другоеto afford the product as a pale yellow resin that
5. 5
   Сушкаby freeze-drying with t-butanol (5 mg, 2% over two steps)

Методика

A suspension of crude [2-(1-benzyl-1H-pyrazol-4-yl)-7-benzyloxy-6-methoxy-benzofuran-3-yl]-(3,4,5-trimethoxyphenyl)-methanone (29 mg), 10% palladium on carbon (20 mg) and 6M HCl(aq) (2 drops) in ethyl acetate (2 mL) and methanol (1 mL) was stirred at room temperature overnight. After this time the reaction mixture was filtered through celite and the solvent removed under vacuum. The crude residue was purified by preparative thin layer chromatography to afford the product as a pale yellow resin that was solidified by freeze-drying with t-butanol (5 mg, 2% over two steps).

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