Реакция #2146781

Уравнение реакции

4-iodo-1H-pyrazole

potassium carbonate

benzyl bromide

→

title compound

Выход 97.0%

1-Benzyl-4-iodo-1H-pyrazole

Выход 97.0%

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураthe reaction was refluxed for 3 h
2. 2
   Концентрированиеwas concentrated onto silica gel in vacuo
3. 3
   Промывкаeluted through a short silica plug (sequential elution—hexane, 10% diethyl ether in hexanes)

Методика

To a stirred suspension of 4-iodo-1H-pyrazole (1.50 g, 7.73 mmol) and potassium carbonate (2.67 g, 19.3 mmol) in acetone was added benzyl bromide (0.96 mL, 8.07 mmol) and the reaction was refluxed for 3 h. After cooling to room temperature the mixture was concentrated onto silica gel in vacuo and eluted through a short silica plug (sequential elution—hexane, 10% diethyl ether in hexanes) to provide the title compound as a white solid (2.12 g, 97% yield).

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