Реакция #2146774

Уравнение реакции

2-(4-Methoxy-benzyl)-7-methyl-6-((R)-pyrrolidin-3-yloxy)-2H-isoquinolin-1-one hydrochloride

trifluoroacetic acid

→

7-Methyl-6-((R)-1-pyrrolidin-3-ylmethoxy)-2H-isoquinolin-1-one hydrochloride

Выход 74.4%

Условия реакции

Обработка

1. 1
   workup.DISTILLATIONThen the excess trifluoroacetic acid was distilled off in vacuo
2. 2
   workup.ADDITIONthe residue was diluted with 10 ml 1 M hydrochloric acid
3. 3
   ПромывкаThe aqueous phase was washed with methylene chloride twice
4. 4
   Другоеdried

Методика

245 mg of 2-(4-Methoxy-benzyl)-7-methyl-6-((R)-pyrrolidin-3-yloxy)-2H-isoquinolin-1-one hydrochloride were dissolved in 1.4 g trifluoroacetic acid and the mixture was heated for 2 h in a microwave oven at 150° C. Then the excess trifluoroacetic acid was distilled off in vacuo and the residue was diluted with 10 ml 1 M hydrochloric acid. The aqueous phase was washed with methylene chloride twice and then it was freeze dried to give 134 mg 7-Methyl-6-((R)-1-pyrrolidin-3-ylmethoxy)-2H-isoquinolin-1-one hydrochloride. Rt=0.92 min (Method B). Detected mass: 245.1 (M+H+).

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