Реакция #2146772

Уравнение реакции

(R)-3-[2-(4-Methoxy-benzyl)-7-methyl-1-oxo-1,2-dihydro-isoquinolin-6-yloxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

trifluoroacetic acid

→

7-Methyl-6-((R)-1-pyrrolidin-3-ylmethoxy)-2H-isoquinolin-1-one

Выход 38.7%

Условия реакции

Обработка

1. 1
   workup.DISTILLATIONThen the excess trifluoroacetic acid was distilled off in vacuo
2. 2
   workup.ADDITIONthe residue was diluted with 10 ml 1 M hydrochloric acid
3. 3
   ПромывкаThe aqueous phase was washed with methylene chloride twice
4. 4
   Другоеdried

Методика

0.53 g (1.1 mmol) (R)-3-[2-(4-Methoxy-benzyl)-7-methyl-1-oxo-1,2-dihydro-isoquinolin-6-yloxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester were dissolved in 2.5 g (22 mmol) trifluoroacetic acid. After 1 h at room temperature the mixture was heated for 2 h in a microwave oven at 150° C. Then the excess trifluoroacetic acid was distilled off in vacuo and the residue was diluted with 10 ml 1 M hydrochloric acid. The aqueous phase was washed with methylene chloride twice and then it was freeze dried to give 0.11 g 7-Methyl-6-((R)-1-pyrrolidin-3-ylmethoxy)-2H-isoquinolin-1-one as the hydrochloride. Rt=0.82 min (Method B). Detected mass: 259.1 (M+H+).

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