Реакция #2146770

Уравнение реакции

water

4-methoxybenzylchloride

6-fluoro-7-methyl-2H-isoquinolin-1-one

caesium carbonate

→

6-Fluoro-2-(4-methoxy-benzyl)-7-methyl-2H-isoquinolin-1-one

Растворители

heptane ethyl acetate

DMF

Условия реакции

Обработка

1. 1
   workup.STIRRINGstirred for 1 h
2. 2
   Фильтрацияthe precipitated product was filtrated by suction
3. 3
   ДругоеFrom the mother liquor additional produced
4. 4
   ДругоеThe combined products were recrystallized from ethyl acetate and 8.39 g 6-fluoro-2-(4-methoxy-benzyl)-7-methyl-2H-isoquinolin-1-one

Методика

To a solution of 9.17 g (51.8 mmol) of 6-fluoro-7-methyl-2H-isoquinolin-1-one in 80 ml DMF were added 20.2 g (62.1 mmol) caesium carbonate and then 8.92 g (56.9 mmol) 4-methoxybenzylchloride. After stirring at room temperature for 90 minutes the reaction mixture was poured into 600 ml water, stirred for 1 h, and then the precipitated product was filtrated by suction. From the mother liquor additional produced was isolated by chromatography with heptane/ethyl acetate (80:20). The combined products were recrystallized from ethyl acetate and 8.39 g 6-fluoro-2-(4-methoxy-benzyl)-7-methyl-2H-isoquinolin-1-one were received.

Источник