Реакция #2146768

Уравнение реакции

p-methoxybenzylchloride

6-fluoro-isoquinolinone

Cs2CO3

→

title compound

Выход 93.7%

6-Fluoro-2-(4-methoxy-benzyl)-2H-isoquinolin-1-one

Выход 93.7%

Растворители

DMF

Условия реакции

Обработка

1. 1
   workup.ADDITIONpoured on ice
2. 2
   ФильтрацияThe precipitate was filtered
3. 3
   Промывкаwashed with water
4. 4
   Другоеdried

Методика

169 μL of p-methoxybenzylchloride (1.24 mmol, 1.1 eq) were added to a suspension of 200 mg of 6-fluoro-isoquinolinone (13) (1.13 mmol) and 368 mg of Cs2CO3 (1.36 mmol, 1.2 eq) in 3 mL of DMF. The mixture was stirred for 2 h and then poured on ice. The precipitate was filtered, washed with water and dried to yield 300 mg of the title compound. LCMS Method B, retention time 1.76 min, detected mass 284.14 [M+H]+

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