Реакция #2146766

Уравнение реакции

[4-(7-Chloro-1-oxo-1,2-dihydro-isoquinolin-6-yloxy)-piperidin-1-yl]-acetic acid ethyl ester

NaOH

→

title compound

Выход 59.5%

[4-(7-Chloro-1-oxo-1,2-dihydro-isoquinolin-6-yloxy)-piperidin-1-yl]-acetic acid

Выход 59.5%

Растворители

methanol

Условия реакции

Обработка

1. 1
   Другоеthe solvent was removed i
2. 2
   workup.DISSOLUTIONand the residue was dissolved in water
3. 3
   workup.ADDITIONby adding 2 N HCl
4. 4
   ФильтрацияFiltration of the precipitate
5. 5
   Другоеdrying

Методика

1.56 g (4.27 mmol) [4-(7-Chloro-1-oxo-1,2-dihydro-isoquinolin-6-yloxy)-piperidin-1-yl]-acetic acid ethyl ester (41) were dissolved in 20 mL of methanol and 20 ml of 2N NaOH were added. After stirring for 1 h at room temperature, the solvent was removed i. vac. and the residue was dissolved in water. The aqueous solution was neutralized by adding 2 N HCl. Filtration of the precipitate and drying gave 856 mg of the title compound. Rt=0.82 min (Method B). Detected mass: 337.1 (M+H+).

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