Реакция #2146764

Уравнение реакции

4-(1-Benzyloxy-7-chloro-isoquinolin-6-yloxy)-piperidine-1-carboxylic acid tert-butyl-ester

→

desired compound

Выход 69.6%

7-Chloro-6-(piperidin-4-yloxy)-2H-isoquinolin-1-one-hydrochloride

Выход 69.6%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ДругоеThe solvent was removed i
2. 2
   Другоеand the residue was purified by preparative HPLC
3. 3
   ДругоеThe product fractions were evaporated
4. 4
   workup.DISSOLUTIONdissolved in 2 N HCl

Методика

254 mg (0.52 mmol) of 4-(1-Benzyloxy-7-chloro-isoquinolin-6-yloxy)-piperidine-1-carboxylic acid tert-butyl-ester (6) were stirred in methanol/2 N HCl (1:1) at room temperature overnight. The solvent was removed i. vac. and the residue was purified by preparative HPLC. The product fractions were evaporated and dissolved in 2 N HCl. Lyophilization results in 57 mg of the desired compound. Rt=0.95 min (Method B). Detected mass: 279.1 (M+H+).

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