Реакция #2146761

Уравнение реакции

7-Chloro-6-fluoro-isoquinoline

3-Chloro-benzene-carboperoxoic acid

→

material

Выход 67.6%

7-Chloro-6-fluoro-isoquinoline 2-oxide

Выход 67.6%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ФильтрацияFor workup, the precipitate was filtered off
2. 2
   Промывкаwashed with dichloromethane
3. 3
   ПромывкаThe filtrate was washed twice with NaHCO3-solution
4. 4
   ДругоеThe layers were separated
5. 5
   Экстракцияthe aqueous phase was extracted twice with dichloromethane
6. 6
   СушкаThe organic phases were dried with MgSO4
7. 7
   Другоеevaporated

Методика

25 g (137.7 mmol) of 7-Chloro-6-fluoro-isoquinoline (3) were in dissolved in 500 ml of dichloromethane. At room temperature 50.9 g (206.5 mmol) of 3-Chloro-benzene-carboperoxoic acid (70%) were added and the mixture was stirred at room temperature until complete conversion is achieved. For workup, the precipitate was filtered off and washed with dichloromethane. The filtrate was washed twice with NaHCO3-solution. The layers were separated and the aqueous phase was extracted twice with dichloromethane. The organic phases were dried with MgSO4 and evaporated. The so obtained solid material (18.4 g) was used without further purification. Rt=0.87 min (Method C). Detected mass: 198.1/200.1 (M+H+).

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