Реакция #2146695

Уравнение реакции

2-bromo-4′-hydroxyacetophenone

2-aminopyridine

sodium hydrogencarbonate

→

2-(4′-hydroxyphenyl)imidazo[1,2-a]pyridine

Выход 63.3%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   ТемператураAfter the reaction solution was cooled down to room temperature
2. 2
   ТемператураThe resulting mixture was refluxed in an oil bath at 100° C. for one hour
3. 3
   ДругоеAfter the completion of the reaction
4. 4
   Температураthe reaction solution was cooled to room temperature
5. 5
   Другоеprecipitates
6. 6
   Фильтрацияwere filtered
7. 7
   Другоеrecovered
8. 8
   ПромывкаThe precipitates were washed with acetonitrile and water
9. 9
   Другоеdried under reduced pressure

Методика

649 mg (corresponding to 3.0 mmol) of 2-bromo-4′-hydroxyacetophenone and 285 mg (corresponding to 3.0 mmol) of 2-aminopyridine were dissolved in 20 mL of acetonitrile. The resulting solution was refluxed in an oil bath at 110° C. for one hour. After the reaction solution was cooled down to room temperature, 254 mg (corresponding to 5.4 mmol) of sodium hydrogencarbonate was added thereto. The resulting mixture was refluxed in an oil bath at 100° C. for one hour. After the completion of the reaction, the reaction solution was cooled to room temperature, and precipitates were filtered and recovered therefrom. The precipitates were washed with acetonitrile and water, and then dried under reduced pressure to obtain 405 mg (corresponding to 1.9 mmol) of 2-(4′-hydroxyphenyl)imidazo[1,2-a]pyridine (FIG. 4, Step 2).

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