Реакция #2146686

Уравнение реакции

2-bromo-4′-hydroxyacetophenone

2-amino-5-methoxypyridine

→

2-(4′-hydroxyphenyl)-6-methoxyimidazo[1,2-a]pyridine

Выход 81.6%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   ДругоеAfter the completion of the reaction
2. 2
   Температураthe reaction solution was cooled down to room temperature
3. 3
   Другоеprecipitates
4. 4
   Фильтрацияwere filtered
5. 5
   Другоеrecovered
6. 6
   ПромывкаThe precipitates were washed with acetonitrile
7. 7
   Другоеdried under reduced pressure
8. 8
   workup.ADDITIONThen, about 20 mL of a saturated sodium hydrogencarbonate solution was added
9. 9
   Другоеthe mixture was sonicated for 5 minutes
10. 10
    ДругоеPrecipitates
11. 11
    Фильтрацияwere filtered
12. 12
    Другоеrecovered from the resulting mixture
13. 13
    Промывкаsufficiently washed with water
14. 14
    Другоеdried under reduced pressure

Методика

2.15 g (corresponding to 10.0 mmol) of 2-bromo-4′-hydroxyacetophenone and 1.25 g (corresponding to 10.0 mmol) of 2-amino-5-methoxypyridine were dissolved in 50 mL, of acetonitrile. The resulting solution was refluxed in an oil bath at 90° C. for 3.5 hours. After the completion of the reaction, the reaction solution was cooled down to room temperature, and precipitates were filtered and recovered. The precipitates were washed with acetonitrile and dried under reduced pressure. The resulting crude crystals were suspended in a mixed solution of 40 mL of water and 40 mL of methanol. Then, about 20 mL of a saturated sodium hydrogencarbonate solution was added thereto, and the mixture was sonicated for 5 minutes using a ultrasonic washing machine. Precipitates were filtered and recovered from the resulting mixture, sufficiently washed with water, and dried under reduced pressure, to obtain 1.96 g (corresponding to 8.16 mmol) of 2-(4′-hydroxyphenyl)-6-methoxyimidazo[1,2-a]pyridine (FIG. 2, Step 5).

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