Реакция #2145397

Уравнение реакции

2-(2-aminoethylthiomethyl)-4-methoxypyridine

1-methylthio-1-methylsulphinyl-2-nitroethylene

→

1-methylthio-1-[2-(4-methoxy-2-pyridylmethylthio)ethylamino)-2-nitroethylene monohydrate

Выход 110.2%

Растворители

methanol

methanol

Условия реакции

Обработка

1. 1
   Другоеwas evaporated to an oil which
2. 2
   Другоеwas crystallised from aqueous ethanol

Методика

A solution of 2-(2-aminoethylthiomethyl)-4-methoxypyridine (3.28 g) in methanol (40 cc) was added over 70 minutes to a stirred solution of 1-methylthio-1-methylsulphinyl-2-nitroethylene (3.01 g) in methanol (200 cc) at 30°. The mixture was allowed to stand overnight at room temperature and was evaporated to an oil which was crystallised from aqueous ethanol to give 1-methylthio-1-[2-(4-methoxy-2-pyridylmethylthio)ethylamino)-2-nitroethylene monohydrate (3.04 g) m.p. 52.5°-54.5°.

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