Реакция #214459

Уравнение реакции

4-amino-2-chloro-6,7-dimethoxyquinazoline

3-(4-piperidinyl)-3-azaspiro-[5,5]-undecan-2,4-dione

sodium carbonate

→

3-[2-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-piperidinyl]-3-azaspiro[5,5]undecan-2,4-dione monohydrochloride

Растворители

dimethylformamide

Условия реакции

Обработка

1. 1
   ФильтрацияIt is filtered
2. 2
   Другоеthe filtrate evaporated
3. 3
   workup.DISSOLUTIONthe residue dissolved in methylene chloride
4. 4
   Промывкаthe solution washed with aqueous sodium carbonate
5. 5
   Другоеdried
6. 6
   Фильтрацияfiltered
7. 7
   Другоеevaporated
8. 8
   ДругоеThe residue is triturated with 50 ml of isopropanol

Методика

The mixture of 2.39 g of 4-amino-2-chloro-6,7-dimethoxyquinazoline, 2.64 g of 3-(4-piperidinyl)-3-azaspiro-[5,5]-undecan-2,4-dione, 2.1 g anhydrous sodium carbonate and 25 ml of dimethylformamide is stirred under nitrogen at 150° for 10 hours. It is filtered, the filtrate evaporated, the residue dissolved in methylene chloride, the solution washed with aqueous sodium carbonate, dried, filtered and evaporated. The residue is triturated with 50 ml of isopropanol, the remainder taken up in isopropanol and the mixture acidified with hydrogen chloride, to yield the 3-[2-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-piperidinyl]-3-azaspiro[5,5]undecan-2,4-dione monohydrochloride melting at 290° (dec.).

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