Реакция #214371

Уравнение реакции

6-chloro-2,4-diaminopyrimidine

methylhydrazine

→

2,4-diamino-6-(1-methylhydrazino)pyrimidine

Выход 56.0%

Растворители

methanol

Условия реакции

Обработка

1. 1
   Другоеcould crystallise out
2. 2
   ФильтрацияThe white solid (3.0 g) was collected by filtration
3. 3
   Другоеdried under reduced pressure at 70° C
4. 4
   ДругоеRecrystallisation of the product from methanol/methylhydrazine (50/l)

Методика

To a refluxing solution of 6-chloro-2,4-diaminopyrimidine (4.0 g) in anhydrous methanol (40 ml) was added methylhydrazine (3.2 g). After 18 hours the refluxing mixture was allowed to cool to room temperature under a nitrogen atmosphere in order that the product could crystallise out. The white solid (3.0 g) was collected by filtration and dried under reduced pressure at 70° C. Recrystallisation of the product from methanol/methylhydrazine (50/l) gave straw-coloured crystals of 2,4-diamino-6-(1-methylhydrazino)pyrimidine (1.92 g; 56% of theoretical yield; M.P. 214°-217° C. decomposition).

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