Реакция #214059

Уравнение реакции

1-bromo-4-chloro-3,3-dimethyl-butan-2-one

4-chlorophenol

potassium carbonate

→

4-chloro-1-(4-chlorophenoxy)-3,3-dimethyl-butan-2-one

Выход 80.7%

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураunder reflux for 15 hours
2. 2
   Температураto cool
3. 3
   Фильтрацияthe inorganic residue was filtered off
4. 4
   Промывкаrinsed with acetone
5. 5
   КонцентрированиеThe filtrate was concentrated
6. 6
   workup.DISTILLATIONby distilling off the solvent in vacuo
7. 7
   Промывкаthe methylene chloride mixture was washed three times with 250 ml of water each time
8. 8
   Сушкаdried over sodium sulphate
9. 9
   workup.DISTILLATIONdistilled

Методика

213.5 g (1 mol) of 1-bromo-4-chloro-3,3-dimethyl-butan-2-one were added dropwise to a boiling suspension of 128.5 g (1 mol) of 4-chlorophenol and 140 g (1 mol) of potassium carbonate in 1,000 ml of absolute acetone. The mixture was stirred under reflux for 15 hours and then allowed to cool and the inorganic residue was filtered off and rinsed with acetone. The filtrate was concentrated by distilling off the solvent in vacuo, the residue was taken up in 1,000 ml of methylene chloride and the methylene chloride mixture was washed three times with 250 ml of water each time, dried over sodium sulphate and distilled. 210 g (80.7% of theory) of 4-chloro-1-(4-chlorophenoxy)-3,3-dimethyl-butan-2-one of boiling point 125°-127° C./0.1 mm were obtained.

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