Реакция #2122515

Уравнение реакции

Chlorosulfonic acid

2-methylbenzoxazole

→

Compound 8

Выход 59.9%

2-methylbenzoxazole-6-sulfonyl chloride

Выход 59.9%

Растворители

Условия реакции

Обработка

1. 1
   Другоеof 15 min
2. 2
   ТемператураAfter cooling
3. 3
   workup.ADDITIONmix
4. 4
   ДругоеThe white solid that separated
5. 5
   Фильтрацияwas collected by filtration
6. 6
   Промывкаwashed with water until washings
7. 7
   Другоеdried

Методика

Chlorosulfonic acid (12.5 ml, 187.8 mmol) was cooled in an ice bath and 2-methylbenzoxazole (5.0 g, 37.5 mmol) was carefully added drop wise over a period of 15 min. The combined mixture was heated at 115-120° C. for 16 hours. After cooling, the mixture was added very slowly to ca. 100 ml ice/water mix. The white solid that separated was collected by filtration, washed with water until washings were neutral and dried to yield 5.2 g (59%) of Compound 8, whose structure is given below:

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