Реакция #2119

Уравнение реакции

diethyl [4-(3-methylxanthin-1-yl)-butyl]phosphonate

ethyl iodide

potassium carbonate

→

Diethyl [4-(7-ethyl-3-methylxanthin-1-yl)butyl]phosphonate

Растворители

DMF

Условия реакции

Обработка

1. 1
   ФильтрацияThe solid was filtered off
2. 2
   Концентрированиеthe filtrate was concentrated under reduced pressure
3. 3
   Фильтрацияfiltered again
4. 4
   Другоеcrystallized from diisopropyl ether

Методика

7.2 g (0.02 mol) of diethyl [4-(3-methylxanthin-1-yl)-butyl]phosphonate were suspended in 100 ml of DMF, treated with 4.7 g (0.03 mol) of ethyl iodide and 4.1 g (0.03 mol) of activated potassium carbonate and heated at 60° C. for 4 hours. The solid was filtered off, the filtrate was concentrated under reduced pressure and the oily residue which remained was taken up in ethyl acetate, filtered again and crystallized from diisopropyl ether.

Источник