Реакция #2116

Уравнение реакции

benzylethyl 4-(7-ethoxymethyl-3-methylxanthin-1-yl)-butylphosphonate

ammonia

→

Monoethyl ammonium [4-(7-ethoxymethyl-3-methylxanthin-1-yl)butyl]-phosphonate

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ФильтрацияThe catalyst was filtered off
2. 2
   Концентрированиеthe filtrate was concentrated under reduced pressure
3. 3
   Другоеthe solution obtained
4. 4
   Другоеafter evaporating the solvent
5. 5
   Другоеwas then crystallized from diisopropyl ether

Методика

6.3 g (0.013 mol) of benzylethyl 4-(7-ethoxymethyl-3-methylxanthin-1-yl)-butylphosphonate were hydrogenated in 100 ml of ethanol over 0.5 g of palladium (10%) on active carbon at room temperature in the course of 4 hours. The catalyst was filtered off, the filtrate was concentrated under reduced pressure, the solution obtained was treated with methanolic ammonia and the residue which remained after evaporating the solvent was then crystallized from diisopropyl ether.

Источник