Реакция #2109

Уравнение реакции

diethyl 5-hydroxypentylphosphonate

3,4-dihydropyran

pyridinium toluene-4-sulfonate

→

Diethyl 5-(tetrahydropyran-2-yloxy)pentylphosphonate

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Температураunder reflux for 16 hours
2. 2
   ПромывкаThe solution was washed with water and saturated sodium hydrogen carbonate solution
3. 3
   Сушкаdried over sodium sulfate
4. 4
   workup.DISTILLATIONdistilled in a bulb tube

Методика

A solution of 66.9 g (0.298 mol) of diethyl 5-hydroxypentylphosphonate, 32.6 g (0.38 mol) of 3,4-dihydropyran and 1 g (0.004 mol) of pyridinium toluene-4-sulfonate in 800 ml of dichloromethane was heated under reflux for 16 hours. The solution was washed with water and saturated sodium hydrogen carbonate solution, dried over sodium sulfate and distilled in a bulb tube.

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