Реакция #2087

Уравнение реакции

diethyl [4-(1-benzyl-3-methylxanthin-7-yl)-butyl]phosphonate

ammonia

→

Diethyl [4-(3-methylxanthin-7-yl)butyl]phosphonate

Растворители

ethanol

Условия реакции

Обработка

1. 1
   ФильтрацияThe catalyst was filtered off
2. 2
   Другоеthe solvent was evaporated under reduced pressure
3. 3
   Другоеthe residue which remained was crystallized from diisopropyl ether

Методика

13 g (0.03 mol) of diethyl [4-(1-benzyl-3-methylxanthin-7-yl)-butyl]phosphonate were suspended in 150 ml of ethanol with 2 g of palladium on activated carbon (10%) and, after addition of 3 ml of concentrated ammonia solution, hydrogenated with shaking at 1.5 bar in the course of 48 hours. The catalyst was filtered off, the solvent was evaporated under reduced pressure and the residue which remained was crystallized from diisopropyl ether.

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