Реакция #2075728

Уравнение реакции

4,6-Dichloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxy-pyrimidine

water

ammonia

→

title compound

Выход 88.0%

6-Chloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxypyrimidin-4-ylamine

Выход 88.0%

Условия реакции

Обработка

1. 1
   Экстракцияextracted with ethyl acetate thrice
2. 2
   ПромывкаThe combined organic phases were washed once with brine
3. 3
   Другоеdried
4. 4
   Другоеevaporated

Методика

4,6-Dichloro-2-(4-chloro-2-fluoro-3-methoxyphenyl)-5-methoxy-pyrimidine (500 mg, 1.5 mmol) was suspended in ammonia saturated ethanol (10 mL) and heated in a CEM microwave at 125° C. for 30 min. The mixture was poured into 15 mL water and extracted with ethyl acetate thrice. The combined organic phases were washed once with brine, dried and evaporated to give the title compound (420 mg, 88% yield: 1H NMR (DMSO-d6) δ 7.59 (dd, 1H), 7.45 (br s, 2H), 7.39 (dd, 1H), 3.91 (s, 3H), 3.76 (s, 3H).

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