Реакция #2069939

Уравнение реакции

3-(2-naphthalen-2-yl-propionylamino)-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester

TFA DCM

→

title compound

Выход 101.6%

3-(2-Naphthalen-2-yl-propionylamino)-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester

Выход 101.6%

Растворители

DCM

Условия реакции

Обработка

1. 1
   Другоеevaporated to dryness
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in DCM
3. 3
   Промывкаthe solution was washed with brine
4. 4
   workup.ADDITIONtreated with NaHCO3 aq. The obtained precipitate
5. 5
   Фильтрацияwas filtered
6. 6
   Промывкаwashed with water and DCM
7. 7
   Другоеdried under vacuum

Методика

2.5 g (5.2 mmol) of 3-(2-naphthalen-2-yl-propionylamino)-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester in 15 ml DCM was treated with 16 ml of (1:1) TFA/DCM. The reaction mixture was stirred for 30 min. and evaporated to dryness. The resulting residue was dissolved in DCM and the solution was washed with brine and then treated with NaHCO3 aq. The obtained precipitate was filtered, washed with water and DCM, and then dried under vacuum to give 2.0 g (quantitative yield) of the title compound.

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