Реакция #2069929

Уравнение реакции

4-cyano-4′-hydroxybiphenyl

allyl bromide

potassium carbonate

2-butanone

→

4-allyloxy-4′-cyanobiphenyl

Выход 91.3%

Растворители

Water

Условия реакции

Обработка

1. 1
   ДругоеA solution prepared
2. 2
   Температураwas refluxed for 7 hours
3. 3
   Промывкаthe organic layer was washed with water
4. 4
   Сушкаdried with anhydrous magnesium sulfate
5. 5
   ДругоеThe solvent was evaporated away
6. 6
   Другоеthe resulting residue was purified through silica gel column chromatography
7. 7
   Другоеfurther recrystallized from ethanol

Методика

A solution prepared by adding 20 g of 4-cyano-4′-hydroxybiphenyl, 20 g of allyl bromide and 25 g of potassium carbonate to 250 ml of 2-butanone was refluxed for 7 hours. Water was added to the reaction solution for liquid-liquid separation, and the organic layer was washed with water and dried with anhydrous magnesium sulfate. The solvent was evaporated away, and the resulting residue was purified through silica gel column chromatography using toluene as an eluent solvent and then further recrystallized from ethanol to obtain 22 g of 4-allyloxy-4′-cyanobiphenyl.

Источник