Реакция #2064

Уравнение реакции

NaOH

ethyl 3,3-bis(diethoxyphosphinyl)propionate

→

title compound

Выход 96.0%

3,3-bis(diethoxylphosphinyl)-propanoic acid

Выход 96.0%

Растворители

water

EtOH

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling
2. 2
   Другоеthe EtOH was evaporated
3. 3
   ЭкстракцияThe product was extracted into dichloromethane (5×50 ml)
4. 4
   СушкаThe organic layer was dried (Na2SO4)
5. 5
   Концентрированиеconcentrated

Методика

A solution of NaOH (4.00 g, 100 mmol) in water (50 ml) was added to a solution of ethyl 3,3-bis(diethoxyphosphinyl)propionate (32.6 g, 87 mmol) in EtOH (100 ml), and heated at 80° C. for 1 hour. After cooling, the EtOH was evaporated, and the residue was acidified to methyl orange with 12N HCl. The product was extracted into dichloromethane (5×50 ml). The organic layer was dried (Na2SO4) and concentrated to give the title compound (28.8 g, 96%) as a viscous oil.

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