Реакция #2062548

ord-c9670a2fe71942ee9844feae60c5860c

Уравнение реакции

CC(=O)OCC(=O)Cl
acetoxyacetic acid chloride
CC(=O)OCC(=O)N(CCOC(C)C)c1ccc(C(=O)N2CCN(CCc3ccc(Cl)cc3)CC2)cc1.Cl
1-{4-[N-(2-isopropyloxyethyl)-N-acetoxyacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride
→
CC(C)OCCNc1ccc(C(=O)N2CCN(CCc3ccc(Cl)cc3)CC2)cc1
1-{4-[N-(2-isopropyloxyethyl)amino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine

Реактанты

CC(=O)OCC(=O)Cl
acetoxyacetic acid chloride
CC(=O)OCC(=O)N(CCOC(C)C)c1ccc(C(=O)N2CCN(CCc3ccc(Cl)cc3)CC2)cc1.Cl
1-{4-[N-(2-isopropyloxyethyl)-N-acetoxyacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride

Реагенты

Нет

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

In a manner analogous to that described in Example 23, 1-{4-[N-(2-isopropyloxyethyl)-N-acetoxyacetylamino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine hydrochloride having a melting point of 130°-132° is obtained from 5 g of 1-{4-[N-(2-isopropyloxyethyl)amino]benzoyl}-4-[2-(4-chlorophenyl)ethyl]piperazine (Example 21) by reaction with acetoxyacetic acid chloride.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US05286728uspto-grants-1994_02