Реакция #2059909

Уравнение реакции

2-(4-benzyl-piperazin-1-yl)-N-methyl-acetamide

→

title compound

Выход 98.9%

N-Methyl-2-piperazin-1-yl-acetamide

Выход 98.9%

Растворители

EtOH

EtOH

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   ФильтрацияThe resulting mixture was filtered through a pad of Celite®
3. 3
   Концентрированиеthe solvent was concentrated in vacuo

Методика

10% Palladium on carbon (115 mg, 10% by wt.) was placed under an inert atmosphere and suspended in EtOH (5 mL). A solution of 2-(4-benzyl-piperazin-1-yl)-N-methyl-acetamide (1.15 g, 4.65 mmol) dissolved in EtOH (18 mL) was added. The reaction mixture was placed under H2 atmosphere (1 Atm pressure) and stirred overnight. The resulting mixture was filtered through a pad of Celite® and the solvent was concentrated in vacuo to give 723 mg (98.9%) of the title compound as a white solid. 1H-NMR (300 MHz, DMSO-d6) 7.61 (broad s, 1H), 2.80 (s, 2H), 2.68 (t, 4H), 2.59 (d, 3H), 2.31 to 2.26 (m, 4H); ES-MS m/z 158.0 [M+H]+, RT (min) 1.13.

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