Реакция #2058084

ord-77337eb6f62b42a7a214fdb09bf48626

Уравнение реакции

CSc1nc(Cc2cccc(Cl)c2)[nH]c(=O)c1C#N
2-(3-chlorobenzyl)-4-(methyl-sulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
C1COCCN1
morpholine
N#Cc1c(N2CCOCC2)nc(Cc2cccc(Cl)c2)[nH]c1=O
title compound
N#Cc1c(N2CCOCC2)nc(Cc2cccc(Cl)c2)[nH]c1=O
2-(3-Chlorobenzyl)-4-(morpholin-4-yl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

In analogy to the preparation of Example 1, 150 mg (0.51 mmol) of 2-(3-chlorobenzyl)-4-(methyl-sulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 448 mg (5.14 mmol) of morpholine to give 109 mg (63% of theory) of the title compound.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08431573B2uspto-grants-2013_04