Реакция #2056344

Уравнение реакции

Methyl 2,5-dihydroxybenzoate

n-hexylamine

→

product

N-n-hexyl 2,5-dihydroxybenzamide

Условия реакции

Обработка

1. 1
   Температураthe mixture is cooled to room temperature
2. 2
   Другоеn-Hexylamine is removed under reduced pressure
3. 3
   workup.DISSOLUTIONThe residue is dissolved in ethyl acetate
4. 4
   Экстракцияfurther extracted with 1 N HCl
5. 5
   ЭкстракцияThe organic layer is extracted with saturated sodium bicarbonate
6. 6
   Сушкаdried over anhydrous sodium sulfate
7. 7
   ДругоеSolvent is removed under reduced pressure

Методика

Methyl 2,5-dihydroxybenzoate (1 g) is dissolved in 10 mL of n-hexylamine. After overnight heating in an oil bath (60° C.), the mixture is cooled to room temperature. n-Hexylamine is removed under reduced pressure. The residue is dissolved in ethyl acetate and further extracted with 1 N HCl. The organic layer is extracted with saturated sodium bicarbonate and dried over anhydrous sodium sulfate. Solvent is removed under reduced pressure to yield the product as an off-white powder.

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