Реакция #2050057

Уравнение реакции

3-Methyl-3-prop-2-ynyloxymethyl-1-oxa-4-aza-spiro[4.5]decane

HCl

→

2-amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol

Выход 102.7%

Растворители

water

Условия реакции

Обработка

1. 1
   Экстракцияextracted thrice with ethyl ether
2. 2
   ДругоеThe two layers were separated
3. 3
   КонцентрированиеThe aqueous layer was concentrated under reduced pressure

Методика

3-Methyl-3-prop-2-ynyloxymethyl-1-oxa-4-aza-spiro[4.5]decane (1.83 g) in an aqueous solution of HCl (6N) (2.73 ml) were refluxed for 1 hr. The reaction mixture was cooled down to room temperature, diluted with water and extracted thrice with ethyl ether. The two layers were separated. The aqueous layer was concentrated under reduced pressure to yield 2-amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol hydrochloric salt (1.205 g) as a white beige solid which was used as such in Stage 3 described below. 1H NMR (DMSO) δ ppm: 8.02 (3H, s br); 5.47 (1H, s br); 4.21 (2H, s); 3.54-3.49 (5H, m); 1.15 (3H, s).

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