Реакция #2045055

Уравнение реакции

6-[4-(6-Benzyloxyhexanoylamino)phenoxy]hexanoic acid methyl ester

→

81

Выход 62.8%

6-[4-(6-Hydroxyhexanoylamino)phenoxy]hexanoic acid methyl ester

Выход 62.8%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ДругоеCatalyst was removed by filtration and methanol
2. 2
   workup.DISTILLATIONdistilled off
3. 3
   ДругоеCrude 81 was purified by column chromatography on silica gel

Методика

6-[4-(6-Benzyloxyhexanoylamino)phenoxy]hexanoic acid methyl ester 80 (10 g, 22.67 mmol) was dissolved in methanol (100 ml) in a pressure vessel, palladium on carbon (5%, 6 grams) added, and the mixture stirred under a hydrogen atm. (4 Kg) for 20 hrs. Catalyst was removed by filtration and methanol distilled off. Crude 81 was purified by column chromatography on silica gel using chloroform as eluant to give pure 81 (5 g, 62.8%) as a white powder. M.p: 73-75.5°

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