Реакция #2045039

Уравнение реакции

6-(4-nitrophenoxy) hexanoic acid methyl ester

6-(4-Nitro-phenoxy)-hexanoic acid methyl ester

→

53

Выход 80.2%

6-(4-Nitrophenoxy)-hexanoic acid

Выход 80.2%

Растворители

HCl

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 16 hours
2. 2
   Фильтрацияfiltered
3. 3
   Другоеdried
4. 4
   Другоеrecrystallised from a mixture of ethyl acetate:hexane (1:6)

Методика

A mixture of 6-(4-nitrophenoxy) hexanoic acid methyl ester 39 (125 g, 468.16 mmol) and concentrated HCl (1250 ml) was refluxed for 16 hours. The reaction mixture was cooled to room temperature, filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 53 (95 g, 80.2%) as a white powder. M.p: 104-107° C.

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