Реакция #2045035

Уравнение реакции

2-(4-Nitro-phenoxy)-propionic acid

ethylene glycol

HCl

→

48

Выход 56.8%

2-(4-Nitro-phenoxy)-propionic acid 2-hydroxy-ethyl ester

Выход 56.8%

Растворители

water

Условия реакции

Обработка

1. 1
   Другоеfor 1½ hours
2. 2
   ДругоеDuring HCl gas bubbling the temp
3. 3
   Другоеrose to 60° C
4. 4
   ДругоеThe crude reaction mass
5. 5
   ЭкстракцияCrude 48 was extracted into chloroform
6. 6
   Сушкаdried over Na2SO4
7. 7
   workup.DISTILLATIONdistilled
8. 8
   Другоеpurified by column chromatography on silica gel

Методика

To a mixture of 2-(4-Nitro-phenoxy)-propionic acid 47 (45 g, 213 mol) and ethylene glycol (135 ml) was passed dry HCl gas for 1½ hours. During HCl gas bubbling the temp. rose to 60° C. The crude reaction mass was poured onto cold water (600 ml). Crude 48 was extracted into chloroform, dried over Na2SO4, distilled and purified by column chromatography on silica gel using hexane as eluant to give pure 48 (28 g, 56.8%) as a syrup.

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