Реакция #2045025

Уравнение реакции

6-(4-Isocyanato-phenoxy)-hexanoic acid methyl ester

ethylene glycol

→

37

Выход 84.0%

6-[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-hexanoic acid methyl ester

Выход 84.0%

Растворители

Water

Условия реакции

Обработка

1. 1
   Другоеrose to 46° C
2. 2
   Фильтрацияcrude 37 was filtered
3. 3
   Другоеdried
4. 4
   Другоеrecrystallised from toluene

Методика

6-(4-Isocyanato-phenoxy)-hexanoic acid methyl ester 36 (15 g, 57 mmol) was added to ethylene glycol (50 ml) at room temperature. The reaction was exothermic and the temperature rose to 46° C. The reaction mixture was allowed to cool to room temperature and later stirred at room temperature for 16 hours. Water (150 ml) was added and crude 37 was filtered, dried and recrystallised from toluene to get pure 37 (12 g, 84%) as a white powder. M.p: 69.5-71.5° C.

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