Реакция #2045020

Уравнение реакции

4-Nitro phenol

K2CO3

methyl chloroacetate

→

31

Выход 72.5%

Methyl(4-Nitro phenoxy)acetate

Выход 72.5%

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураrefluxed for 12 hours
2. 2
   workup.DISTILLATIONAcetone was distilled off
3. 3
   workup.ADDITIONwater (1500 ml) added
4. 4
   ФильтрацияCrude 31 was filtered
5. 5
   Другоеdried
6. 6
   Другоеrecrystallised from a mixture of ethyl acetate:hexane (1:5)

Методика

To a mixture of 4-Nitro phenol (100 g, 719 mmol) and anhydrous K2CO3 (400 g, 2.894 moles) in anhydrous acetone (950 ml) was added methyl chloroacetate (114 g, 1.050 moles) and refluxed for 12 hours. Acetone was distilled off and water (1500 ml) added. Crude 31 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 31 (110 g, 72.5%) as a white fluffy powder. M.p: 97-98.4° C.

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