Реакция #2045018

Уравнение реакции

(4-Isocyanato-phenoxy)-acetic acid methyl ester

ethylene glycol

→

29

Выход 82.9%

[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-acetic acid methyl ester

Выход 82.9%

Растворители

Water

Условия реакции

Обработка

1. 1
   Фильтрацияcrude 29 was filtered
2. 2
   Другоеdried
3. 3
   Другоеpurified by column chromatography on silica gel

Методика

(4-Isocyanato-phenoxy)-acetic acid methyl ester 28 (15 g, 72.46 mmol) was added to ethylene glycol (30 ml) at room temperature. The reaction was exothermic and the temperature raised to 42° C. Later the reaction mixture was stirred at room temperature for 16 hours. Water (100 ml) was added and crude 29 was filtered, dried and purified by column chromatography on silica gel using chloroform as eluant to get pure 29 (16.17 g, 82.9%) as a off-white powder. M.p: 85.5-87.5° C.

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