Реакция #2045014

Уравнение реакции

Benzyloxyacetic acid 4-acetylamino-phenyl ester

Benzyloxy-acetic acid 4-acetylamino-phenyl ester

→

25

Выход 57.4%

Hydroxy-acetic acid 4-acetylamino-phenyl ester

Выход 57.4%

Растворители

methanol

Условия реакции

Обработка

1. 1
   ДругоеThe catalyst was removed by filtration
2. 2
   workup.DISTILLATIONthe methanol was then distilled off
3. 3
   ДругоеThe crude 25 was recrystallized from mixture of chloroform:methanol (1:4)

Методика

Benzyloxyacetic acid 4-acetylamino-phenyl ester 24 (15 g, 50 mmol) was dissolved in methanol (150 ml) in a pressure vessel, palladium on carbon (5%, 8 grams) added and the mixture stirred under an atmosphere of hydrogen (3 Kg) for 20 hours. The catalyst was removed by filtration and the methanol was then distilled off. The crude 25 was recrystallized from mixture of chloroform:methanol (1:4) to get pure 25 (6 g, 57.2%) as a white powder. M.p: 144-146° C.

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