Реакция #2045013

Уравнение реакции

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester

→

23

Выход 71.1%

[2-(4-Amino-phenoxy)-ethoxy]-acetic acid methyl ester

Выход 71.1%

Растворители

ethyl acetate

Условия реакции

Обработка

1. 1
   ФильтрацияThe catalyst was filtered
2. 2
   Концентрированиеthe filtrate concentrated
3. 3
   workup.ADDITIONhexane (3 ml) added
4. 4
   Фильтрацияthe solid filtered

Методика

[2-(4-Nitrophenoxy)-ethoxy]acetic acid methyl ester 22 (1 g, 3.9 mmol) was dissolved in anhydrous ethyl acetate (20 ml), palladium carbon (10%, 0.1 g) added and the mixture stirred under an atmosphere of hydrogen using balloon for 30 minutes. The catalyst was filtered, the filtrate concentrated, hexane (3 ml) added, and the solid filtered to give 23 (625 mg, 70.9%) as a light brown powder. The melting point was found to be 51-52.5° C. The structure was confirmed with IR and NMR.

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