Реакция #2045007

Уравнение реакции

2-(4-Acetylaminophenoxy)propionic acid methyl ester

2-(4-Acetylamino-phenoxy)-propionic acid methyl ester

→

17

Выход 98.1%

2-(4-Amino-phenoxy)-propionic acid

Выход 98.1%

Растворители

hydrochloric acid

Условия реакции

Обработка

1. 1
   Температураwas refluxed for 48 hours
2. 2
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
3. 3
   Фильтрацияfiltered hot
4. 4
   Фильтрацияfiltered
5. 5
   Другоеdried

Методика

A mixture of 2-(4-Acetylaminophenoxy)propionic acid methyl ester 16 (320 grams, 1.35 mol) in concentrated hydrochloric acid (8 liters) was refluxed for 48 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 17 (240 g, 81.7%) as a brown powder. The melting point was found to be 175-180° C.

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