Реакция #2045003

Уравнение реакции

Paracetamol

K2CO3

ethyl bromoacetate

→

13

Выход 80.1%

(4-Acetylamino-phenoxy)-acetic acid ethyl ester

Выход 80.1%

Растворители

acetone

Условия реакции

Обработка

1. 1
   Температураrefluxed for 16 hours
2. 2
   workup.DISTILLATIONAcetone was distilled off
3. 3
   workup.ADDITIONwater (5 liter) was added
4. 4
   ФильтрацияCrude 13 was filtered
5. 5
   Другоеdried
6. 6
   Другоеrecrystallised from a mixture of toluene:hexane (1:5)

Методика

To a mixture of Paracetamol (300 g, 1.984 mol), and anhydrous K2CO3 (1.80 Kg, 7.814 mmol) in anhydrous acetone (3 liters) was added ethyl bromoacetate (452 gr, 2.7 mol) and refluxed for 16 hours. Acetone was distilled off and water (5 liter) was added. Crude 13 was filtered, dried and recrystallised from a mixture of toluene:hexane (1:5) to give pure 13 (377 g, 80%) as a white shining powder. The melting point was found to be 104.2-106.2° C.

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